Let's break this down step by step:

Expression: $-4 \times 6^2 \div 6 - (42 + 5)$

1. First, evaluate $6^2$: $6^2 = 36$

2. Next, multiply by $-4$: $-4 \times 36 = -144$

3. Now divide by 6: $-144 \div 6 = -24$

4. Evaluate the expression inside the parentheses: $42 + 5 = 47$

5. Finally, subtract 47 from $-24$: $-24 - 47 = -71$

So, the result of the expression is: $\boxed{-71}$

Do you need further details or have any questions?

Here are 5 related questions to deepen your understanding:

1. What happens if the exponent is changed to 3, i.e., $-4 \times 6^3 \div 6 - (42 + 5)$?
2. How would the result change if you add a negative number inside the parentheses, like $-4 \times 6^2 \div 6 - (42 - 5)$?
3. Can you simplify the expression if the division comes first, i.e., $-4 \div 6 \times 6^2 - (42 + 5)$?
4. What is the effect of swapping the order of multiplication and division in this expression?
5. What would happen if the parentheses around $42 + 5$ were removed?

Tip: Always follow the order of operations (PEMDAS: Parentheses, Exponents, Multiplication and Division (left to right), Addition and Subtraction (left to right)) to avoid mistakes in simplifying expressions.